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A total of three % of Energetic compound is excreted in urine as unchanged Lively material. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, that are even more metabolised by conjugation. As a result, Lively compound metabolism mediated by cytochrome P450 meth